Toll-like Receptor (TLR) Signaling and Differential Activation of PGC Family Genes in a Mouse Model of Staphylococcus aureus Sepsis
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Toll-like Receptor (TLR) Signaling and Differential Activation of PGC Family Genes in a Mouse Model of Staphylococcus aureus Sepsis by Timothy Elisha Sweeney Department of Pathology Duke University Date:____5/20/2010________ Approved: ___________________________ Claude A. Piantadosi, MD, Supervisor ___________________________ Soman N. Abraham, PhD ___________________________ Salvatore V. Pizzo, MD, PhD ___________________________ Patrick C. Seed, MD, PhD ___________________________ Hagir B. Suliman, DVM, PhD An abstract of a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pathology in the Graduate School of Duke University
منابع مشابه
A Toll-Like Receptor 2 Pathway Regulates the Ppargc1a/b Metabolic Co-Activators in Mice with Staphylococcal aureus Sepsis
Activation of the host antibacterial defenses by the toll-like receptors (TLR) also selectively activates energy-sensing and metabolic pathways, but the mechanisms are poorly understood. This includes the metabolic and mitochondrial biogenesis master co-activators, Ppargc1a (PGC-1α) and Ppargc1b (PGC-1β) in Staphylococcus aureus (S. aureus) sepsis. The expression of these genes in the liver is ...
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تاریخ انتشار 2010